Πλοήγηση ανά Συγγραφέα "Maragozidis, P."
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Alterations of Deadenylase Expression in Acute Leukemias: Evidence for Poly(A)-Specific Ribonuclease as a Potential Biomarker
Maragozidis, P.; Karangeli, M.; Labrou, M.; Dimoulou, G.; Papaspyrou, K.; Salataj, E.; Pournaras, S.; Matsouka, P.; Gourgoulianis, K. I.; Balatsos, N. A. A. (2012)Background/Aims: The degradation of mRNA is a key process in the control of gene expression correlated to anomalous cell proliferation. The rate-limiting step of mRNA degradation is the removal of the poly(A) tail by ... -
Competitive Inhibition of Human Poly(A)-Specific Ribonuclease (PARN) by Synthetic Fluoro-Pyranosyl Nucleosides
Balatsos, N. A. A.; Vlachakis, D.; Maragozidis, P.; Manta, S.; Anastasakis, D.; Kyritsis, A.; Vlassi, M.; Komiotis, D.; Stathopoulos, C. (2009)Poly(A)-specific ribonuclease (PARN) is a cap-interacting deadenylase that mediates, together with other exonucleases, the eukaryotic mRNA turnover and thus is actively involved in the regulation of gene expression. ... -
Cysteinyl leukotriene receptors in tonsillar B- and T-lymphocytes from children with obstructive sleep apnea
Tsaoussoglou, M.; Lianou, L.; Maragozidis, P.; Hatzinikolaou, S.; Mavromati, M.; Orologas, N.; Panaghiotopoulou-Gartagani, P.; Rassidakis, G.; Balatsos, N. A. A.; Chrousos, G.; Kaditis, A. G. (2012)Objectives: Cysteinyl leukotrienes have been implicated in the pathogenesis of adenotonsillar hypertrophy in children with obstructive sleep apnea (OSA). This study aimed to quantify the expression of cysteinyl leukotriene ... -
Effect of natural nucleotides and their synthetic analogues on mRNA turnover by human poly(A)specific ribonuclease (PARN)
Balatsos, N.; Anastasakis, D.; Maragozidis, P.; Manta, S.; Komiotis, D.; Stathopoulos, C. (2008) -
Expression of biosynthetic enzymes for leukotrienes B4 and C4 in tonsillar tissue of children with OSA
Tsaoussoglou, M.; Hatzinikolaou, S.; Lianou, L.; Maragozidis, P.; Balatsos, N.; Panaghiotopoulou-Gartagani, P.; Chrousos, G.; Kaditis, A. (2013) -
Expression of Leukotriene Biosynthetic Enzymes in Tonsillar Tissue of Children With Obstructive Sleep Apnea A Prospective Nonrandomized Study
Tsaoussoglou, M.; Hatzinikolaou, S.; Baltatzis, G. E.; Lianou, L.; Maragozidis, P.; Balatsos, N. A. A.; Chrousos, G.; Kaditis, A. G. (2014)IMPORTANCE Cysteinyl leukotrienes (CysLTs) potentially promote adenotonsillar hypertrophy in children with obstructive sleep apnea (OSA). Previous studies have identified CysLTs and their receptors in tonsillar tissue from ... -
Interleukin-27 improves the ability of adenosine deaminase to rule out tuberculous pleural effusion regardless of pleural tuberculosis prevalence
Skouras, V. S.; Magkouta, S. F.; Psallidas, I.; Tsilioni, I.; Maragozidis, P.; Gourgoulianis, K. I.; Kalomenidis, I. (2015)Background: Interleukin-27 (IL-27) has been proposed to be useful for diagnosing tuberculous pleural effusion (TPE). Adenosine deaminase (ADA) has been long used for the same purpose. The aim of this study was to compare ... -
Modulation of Poly(A)-specific Ribonuclease (PARN): Current Knowledge and Perspectives
Balatsos, N. A. A.; Maragozidis, P.; Anastasakis, D.; Stathopoulos, C. (2012)Deadenylation is the exoribonucleolytic shortening of eukaryotic poly(A) tails. It is often the first and rate-limiting step for mRNA decay and translational silencing. The process is catalysed by a diversity of deadenylases, ... -
Obstructive Sleep Apnea, Excessive Daytime Sleepiness, and Morning Plasma TNF-alpha Levels in Greek Children
Alexopoulos, E. I.; Theologi, V.; Malakasioti, G.; Maragozidis, P.; Tsilioni, I.; Chrousos, G.; Gourgoulianis, K.; Kaditis, A. G. (2013)Background: Obstructive sleep apnea (OSA) has been associated with increased frequency of excessive daytime sleepiness (EDS). Increased plasma TNF-alpha levels may mediate this association in adults, but conflicting results ... -
Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation
Parmenopoulou, V.; Chatzileontiadou, D. S. M.; Manta, S.; Bougiatioti, S.; Maragozidis, P.; Gkaragkouni, D. N.; Kaffesaki, E.; Kantsadi, A. L.; Skamnaki, V. T.; Zographos, S. E.; Zounpoulakis, P.; Balatsos, N. A. A.; Komiotis, D.; Leonidas, D. D. (2012)Five ribofuranosyl pyrimidine nucleosides and their corresponding 1,2,3-triazole derivatives have been synthesized and characterized. Their inhibitory action to Ribonuclease A has been studied by biochemical analysis and ...